Open AccessModulation of extracellular matrix proteins and hepatate stellate cell activation following gadolinium chloride induced Kuffer cell blockade in an experimental model of liver fibrosis/cirrhosis
Author(s) -
Nilgün Tekkeşin,
Yavuz Taga,
Aydın Sav,
Süheyla Bozkurt
Publication year - 2013
Publication title -
qscience connect
Language(s) - English
Resource type - Journals
ISSN - 2223-506X
DOI - 10.5339/connect.2013.17
Subject(s) - hepatic stellate cell , cirrhosis , fibronectin , laminin , myofibroblast , extracellular matrix , fibrosis , kupffer cell , chemistry , hepatic fibrosis , pathology , ccl4 , endocrinology , medicine , carbon tetrachloride , biochemistry , organic chemistry
Hepatic fibrosis is now regarded as a common response to chronic liver injury; regardless of its nature (viral infections, alcohol abuse and metal overload). It is also characterized by excessive deposition of extracellular matrix (ECM) components. The ECM is a dynamic complex of macromolecules that includes collagens, glycoproteins, and proteoglycans, such as laminin and fibronectin; it has been shown that it does not only support the tissue structure, but also plays a major role in cell adhesion, proliferation, and differentiation. Remodelling of the ECM may be the signal that facilitates lobular reorganization during liver regeneration after a liver injury. Much work has been done concerning the ECM synthesis and protein contents