Open AccessAggressiveness of Breast Carcinoma in Young Pre-Menopausal Patients
Author(s) -
Remisha Zahid Shah,
Zahid Mehmood Akhtar,
Safeena Sarfraz,
Syed Hassan Raza Bokhari,
Nazia Noor,
Attia Lateef
Publication year - 2022
Publication title -
pakistan journal of medical and health sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.114
H-Index - 7
ISSN - 1996-7195
DOI - 10.53350/pjmhs2216478
Subject(s) - medicine , breast cancer , malignancy , histopathology , ductal carcinoma , gynecology , stage (stratigraphy) , cancer , mastectomy , carcinoma , oncology , obstetrics , pathology , paleontology , biology
Background: Breast cancer is the most commonly diagnosed malignancy in female population. Aim: To determine and compare the frequency of aggressiveness of breast cancer in pre and post-menopausal patients. Study design: Cross sectional study Place and duration of Study: Department of Histopathology, K.E. Medical University Lahore from 1st January 2016 to 31st December 2018. Methodology: One hundred and fifty female patients diagnosed with breast cancer to assess the aggressiveness of breast cancer in young - premenopausal patients. Post-Surgical Modified Radical Mastectomy specimens were submitted and evaluated for grade, stage, involved lymph nodes, tumor size and metastasis. Results: Sixty four percent of the tumors were left sided and the invasive ductal carcinoma was the most dominant histologic type (96%). Ninety two patients were premenopausal while 58 were post-menopausal. Nodal positivity in patients less than 40 years was more pronounced (74.2% versus 56.8%, p=0.029). Conclusion: Young premenopausal patients represent high risk group for advanced breast cancer. Key words: Breast Cancer, Young, Premenopausal, Post-menopausal, Invasive Ductal Carcinoma