Open AccessDiagnostic Accuracy of Diffusion Weighted MRI in Diagnosing Brain Abscess Taking Histopathology as Gold Standard
Author(s) -
M. Haseeb Iqbal,
Ummara Siddique Umer,
Muhammad Salman Rafique,
Abdullah Safi,
Sana Kundi,
Mahwish Jabeen,
Aliya Sharif
Publication year - 2022
Publication title -
pakistan journal of medical and health sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.114
H-Index - 7
ISSN - 1996-7195
DOI - 10.53350/pjmhs2216452
Subject(s) - histopathology , gold standard (test) , medicine , brain abscess , diffusion mri , magnetic resonance imaging , abscess , radiology , diagnostic accuracy , lesion , nuclear medicine , surgery , pathology
Aim: Diagnostic accuracy of DW-MRI in diagnosing brain abscess taking histopathology as gold standard. Methodology: A total of 407 patients having focal brain lesion on MRI of age 20-50 years of either gender were included. Patients with history of brain surgery, already established diagnosis on histopathology, claustrophobia and pregnant or breast feeding females were excluded. DW-MRI was done and conventional MRI sequences on 1.5 tesla MRI machine and presence or absence of brain abscess was noted. DW-MRI findings were correlated with histopathology. Results: Mean age was 38.53 ± 7.59 years. Out of these 407 patients, 262 (64.37%) were male and 145 (35.63%) were females with ratio of 1.8:1. Mean duration of disease was 4.87 ± 2.40 months. Mean size of lesion was 7.69 ± 4.52 mm. In DW-MRI positive patients, 221 were true positive and 32 were false positive. Among 154, DW-MRI negative patients, 18 were false negative whereas 136 were true negative (P-value=0.01). So in diagnosis of abscess in brain, sensitivity, specificity, PPV, NPV and DA of DW-MRI was 92.5%, 80.96%, 87.4%, 88.3% and 87.7% respectively. Conclusion: DW-MRI is the non-invasive modality of choice having high diagnostic accuracy (DA) i.. 87.7% in diagnosing brain abscess with sensitivity of 92.5% and specificity of 80.96%. Keywords: Brain abscess, diffusion weighted imaging, sensitivity.