Open AccessBiochemical and Histophysiological impact of Curcumin on Breast Cancer. A Cross Sectional Clinical Study
Author(s) -
Naveed Shuja,
Uzma Hameed,
Hasan Akbar Khan,
Allah Wadhayo Kalo,
Urwa Sarwar,
Muhammad Waqas Khan
Publication year - 2022
Publication title -
pakistan journal of medical and health sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.114
H-Index - 7
ISSN - 1996-7195
DOI - 10.53350/pjmhs22163462
Subject(s) - curcumin , carcinoembryonic antigen , curcuma , medicine , breast cancer , cancer , cancer antigen , oncology , gastroenterology , traditional medicine , pharmacology
Hypothesis: The active anti-carcinogenic compound of Curcuma longa a member of ginger family is curcumin which inhabit the growth of tumor in breast cancer. Aims and objectives: The aims and objectives of present study were to determine the clinical and preclinical effects of curcumin against breast cancer. Materials and Methods: 100 women patients with grade- I and grade-II breast cancer were treated with 10g/day curcumin powder orally for six months. The tumor markers such as CA 15-3, CA 27.29, Carcinoembryonic antigen (CEA) and CA 125 were measured from blood serum of each patient. Conclusion: In the present study it was concluded that a significant changes (p<0.05) come out after 6 month in blood serum levels of 10mg/day oral curcumin treated group-B and group–D as compared to group-A and group-C regarding tumor markers such as CA 15-3, CA 27.29, Carcinoembryonic antigen (CEA) and CA 125. Keywords: Curcuma longa, Breast cancer, Carcinoembryonic antigen, Tumor markers, Curcumin