Open AccessGABAergic Modulation in Movement Related Oscillatory Activity: A Review of the Effect Pharmacologically and with Aging
Author(s) -
Christopher L. Groth,
Anneliese A. Singh,
Qiang Zhang,
Brian D. Berman,
Nandakumar S. Narayanan
Publication year - 2021
Publication title -
tremor and other hyperkinetic movements
Language(s) - English
Resource type - Journals
ISSN - 2160-8288
DOI - 10.5334/tohm.655
Subject(s) - gabaergic , neuroscience , magnetoencephalography , beta rhythm , gamma aminobutyric acid , inhibitory postsynaptic potential , electroencephalography , psychology , medicine , biology , receptor
Gamma-aminobutyric acid (GABA) is a ubiquitous inhibitory neurotransmitter critical to the control of movement both cortically and subcortically. Modulation of GABA can alter the characteristic rest as well as movement-related oscillatory activity in the alpha (8–12 Hz), beta (13–30 Hz, and gamma (60–90 Hz) frequencies, but the specific mechanisms by which GABAergic modulation can modify these well-described changes remains unclear. Through pharmacologic GABAergic modulation and evaluation across the age spectrum, the contributions of GABA to these characteristic oscillatory activities are beginning to be understood. Here, we review how baseline GABA signaling plays a key role in motor networks and in cortical oscillations detected by scalp electroencephalography and magnetoencephalography. We also discuss the data showing specific alterations to baseline movement related oscillatory changes from pharmacologic intervention on GABAergic tone as well as with healthy aging. These data provide greater insight into the physiology of movement and may help improve future development of novel therapeutics for patients who suffer from movement disorders.