Open AccessAlexander Disease
Author(s) -
Laura Hartog,
Sven Dekeyzer,
Stephanie Vanden Bossche
Publication year - 2021
Publication title -
journal of the belgian society of radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.232
H-Index - 24
ISSN - 2514-8281
DOI - 10.5334/jbsr.2588
Subject(s) - leukodystrophy , macrocephaly , medicine , disease , differential diagnosis , white matter , pathology , krabbe disease , radiology , magnetic resonance imaging
Main teaching point: The main differential diagnosis of leukodystrophy associated with macrocephaly consists of Alexander disease, Canavan disease, and megalencephalic leukodystrophy with subcortical cysts. Distinguishing imaging characteristics of Alexander disease are an apicoposterior gradient of white matter involvement and a periventricular T2-hypointense rim.