Open AccessA Flare for the Unexpected: Bone Flare as Response to Tyrosine Kinase Inhibitor Treatment in a Lung Cancer Patient
Author(s) -
Charlotte De Bondt,
Annemiek Snoeckx,
Jo Raskin
Publication year - 2020
Publication title -
journal of the belgian society of radiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.232
H-Index - 24
ISSN - 2514-8281
DOI - 10.5334/jbsr.1907
Subject(s) - medicine , flare , lung cancer , tyrosine kinase inhibitor , tyrosine kinase , cancer , cancer research , oncology , receptor , physics , astrophysics
We report the case of a 72-year-old female never-smoker with stage IV endothelial growth factor receptor (EGFR) mutated lung adenocarcinoma. This patient was started on first line tyrosine kinase inhibitor (TKI) and seemingly developed new bone metastases under this treatment. As there was a remarkable discrepancy between the partial response seen in the primary tumor and non-osseous metastatic locations, the possibility of a bone flare phenomenon was considered. In this case report, we demonstrate that new bony lesions are not always synonymous with disease progression.