Open AccessValidation of Whole Blood Rapid Diagnosis Test for Hepatitis B
Author(s) -
José D. Debes,
Gertine van Oord,
André Boonstra
Publication year - 2020
Publication title -
annals of global health
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.602
H-Index - 66
ISSN - 2214-9996
DOI - 10.5334/aogh.2866
Subject(s) - hbsag , medicine , point of care testing , whole blood , hepatitis b virus , rapid diagnostic test , point of care , blood test , virology , diagnostic test , hepatitis b , test (biology) , immunology , virus , emergency medicine , pathology , biology , paleontology
We recently published a report validating point-of-care rapid diagnostic tests (RDT) for the diagnosis of Hepatitis B virus (HBV) infection in serum. In the current report, we validated a whole-blood RDT for HBsAg in the form of a test-strip. The test was validated in 55 HBV positive individuals across all genotypes other than F, and in 20 HBV negative individuals in the Netherlands. The RDT showed 100% sensitivity and specificity. The low cost and use in whole blood allows this RDT to be useful in resource-limited locations, further validation in such settings will be of importance.