Open AccessAssessment of Role of Platelet Aggregation in Metastatic Breast Cancer Patients
Author(s) -
A. Ramji,
C V Shanmugan
Publication year - 2022
Publication title -
annals of international medical and dental research
Language(s) - English
Resource type - Journals
eISSN - 2395-2822
pISSN - 2395-2814
DOI - 10.53339/aimdr.2022.8.1.11
Subject(s) - medicine , platelet , breast cancer , thrombin , platelet aggregation , metastatic breast cancer , adenosine diphosphate , metastasis , gastroenterology , cancer , oncology
Background: To assess role of platelet aggregation in metastatic breast cancer patients.Methods:40 cases (Group I) of metastatic breast cancer patients and equal number of healthy control (Group II) subjects were included. Platelet aggregation studies in vitro using ADP and Thrombin were performed using an optical aggregometer. Detection of platelet aggregation was done by Chrono log series 490 dual and four channel optical aggregometer systems.Results:There were 4 subjects in group I and 12 in group II having ADP 72. Low thrombin 82 among 29 in group I respectively. Amongst patients with normal platelet count, 14 patients had platelet aggregation with ADP in the normal range and 4 patients had platelet aggregation with ADP in the lower range. In patients with high platelet count, 12 showed aggregation in the normal range, and 10 patients showed aggregation in the higher range which was statistically significant (P< 0.05) (Table III, Graph II).Conclusion: Platelet aggregation has an important part to play in the tumor metastasis of breast cancer patients.