Efecto antiinflamatorio de extractos etanólicos de Morinda citrifolia L. en conejos

Morinda citrifolia L. has multiple therapeutic properties, particularly as an anti-inflammatory. The species has been widely studied, however, it is necessary to expand studies to document the presence of secondary metabolites and the anti-inflammatory effect of its extracts in animal models. The objective of the present paper was to identify the secondary metabolites present in the ethanol extracts of leaves and fruit of Morinda citrifolia L. collected in the community of San José Rio Manso, municipality of Lalana Choapam, Oaxaca, as well as the evaluation of its anti-inflammatory effect in rabbits. Ethanol extracts were obtained from the green and mature leaves, as well as the juice of the fruit. Green leaf extract gels were prepared and used in a completely randomized experiment in rabbits. The presence of alkaloids, leucoantacionins, amino acids, coumarins, cardiotonics, flavonoids, terpenes and tannins was identified. The 0.5% extract was more efficient at reducing the inflamed area by 55.6% compared to 28.6% of the control, 48 hours after the induction of inflammation. No signs of adverse reactions due to the use of the pharmaceutical forms evaluated were observed.