Open AccessCÓMO SE REPLICA EL SARS-CoV-2?
Author(s) -
Elmer Joel Casarrubias,
Gualberto Aguilar Torres,
Verónica Rocío Vásquez-Garzón
Publication year - 2020
Publication title -
ra rió guendaruyubi
Language(s) - English
Resource type - Journals
eISSN - 2594-0562
pISSN - 2594-0554
DOI - 10.53331/rar.v3i9.3905
Subject(s) - biology , coronavirus , viral replication , replication (statistics) , biogenesis , microbiology and biotechnology , computational biology , virology , genetics , virus , covid-19 , gene , disease , medicine , pathology , infectious disease (medical specialty)
The scientific community has worked on strong responses by accelerating research and innovation and has rapidly laid the foundation for understanding the molecular determinants of the current novel coronavirus disease (SARS-CoV-2) pandemic. Replication of the viral genome within infected cells is a key stage in the life cycle of SARS-CoV-2. It is a complex process that involves the action of various viral and host proteins to perform RNA polymerization, proofreading, and final tampon. The cellular receptor that has been identified for the SARS-CoV-2 spike (S) glycoprotein is an angiotensin-converting enzyme 2 (ACE2). Primary interactions between S and host cell factors during the early replication cycle of the coronavirus initiate biogenesis of replication organelles. Although the mechanisms underlying the formation of replication organelles are not fully understood, in this review we provide an update on structural and functional data on key players in the SARS-CoV-2 replication machinery.