Open AccessHPV infection and endometriosis: a systematic review and meta-analysis
Author(s) -
Geilson Gomes de Oliveira,
José Eleutério,
Renata Mírian Nunes Eleutério
Publication year - 2019
Publication title -
dst
Language(s) - English
Resource type - Journals
eISSN - 2177-8264
pISSN - 0103-4065
DOI - 10.5327/dst-2177-8264-201931406
Subject(s) - endometriosis , meta analysis , medicine , cochrane library , scopus , relative risk , confidence interval , medline , risk factor , gynecology , obstetrics , biology , biochemistry
Recent research has focused on the role of persistent ascending bacterial infections and sexually transmitted infections (STI) as a factor associated to endometriosis. Indeed, some studies investigated the possible role of HPV in endometriosis, but this topic remains inconclusive. Objective:The present study aims to meta-analyze research that assessed the presence of HPV infection in patients with endometriosis. Methods: MEDLINE, Embase, Scopus, LILACS, Cochrane Library, and OpenGrey were searched until February 10th, 2020. Search terms included “endometriosis” and “HPV” without language restrictions. The combined relative risks and 95% confidence interval (95%CI) were calculated, and heterogeneity was assessed with I-square (I2 ). Results: Meta-analysis with low heterogeneity found a relative risk of twice as much in women exposed to HPV in relation to the unexposed control. Conclusion: Results indicate that HPV could be a risk factor for developing endometriosis.