Open AccessTHE ACCURACY OF TRANSCRANIAL SONOGRAPHY ON ALZHEIMER’S DISEASE DIAGNOSIS
Author(s) -
Rejane Barbosa Santos,
Rita de Cássia Leite Fernandes
Publication year - 2021
Publication title -
dementia and neuropsychologia
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 0.54
H-Index - 21
ISSN - 1980-5764
DOI - 10.5327/1980-5764.rpda044
Subject(s) - medicine , neuroimaging , dementia , temporal lobe , reproducibility , magnetic resonance imaging , radiology , echogenicity , neuropsychology , atrophy , nuclear medicine , outpatient clinic , audiology , disease , ultrasound , pathology , epilepsy , psychiatry , cognition , statistics , mathematics
Background: The diagnosis of Alzheimer’s disease (AD) is clinical, combining neurological examination, neuropsychological tests and neuroimaging. One of the anatomical features of AD is medial temporal lobe (MTL) atrophy graduated by magnetic resonance imaging (MRI) with accuracy to discriminate between healthy controls, mild neurocognitive disorder (MCI) or dementia, but it has its limitations. Transcranial sonography (TCS) demonstrated good accuracy to display changes in echogenicity or size of intracranial structures. Objective: The objective of this study is to evaluate TCS diagnostic accuracy in AD. Methods: Prospective cross-sectional case-control study. Patients in the outpatient unit of a University Hospital with >2 y AD diagnosis and controls. TCS performed with a 2-4MHz sector probe to study lateral temporal lobe (A), MTL height (B) and width (C), ambiens cistern width (D) and choroidal cistern height (E). Results: TCCS exams were performed. 2 individuals had no bone window (1 control, 1 AD). 15 healthy controls and 4 DA patients showed significantly different B/E measurements (3.17+0,47 cm2 vs 2.23+0.22 cm2; p=0,0001). Conclusions: Our preliminary results indicate that our measurements are in agreement with those found in the literature. The present results indicate the reproducibility of the technique in our Hospital and encourages us to expand the number of participants.