Open AccessTHE ADDENBROOKE’S COGNITIVE EXAMINATION–REVISED (ACE-R) IN THE DIFFERENTIAL DIAGNOSIS BETWEEN ALZHEIMER’S DISEASE AND BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA: A POWERFUL LOGARITHM
Author(s) -
Viviane Amaral Carvalho,
Thais Lima- Silva,
Luciano Inácio Mariano,
Leonardo de Souza,
Henrique Cerqueira Guimarães,
Valéria Santoro Bahia,
Ricardo Nitríni,
Maira Tonidandel Barbosa,
Mônica Sanches Yassuda,
Paulo Caramelli
Publication year - 2021
Publication title -
dementia and neuropsychologia
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 0.54
H-Index - 21
ISSN - 1980-5764
DOI - 10.5327/1980-5764.rpda017
Subject(s) - frontotemporal dementia , dementia , logistic regression , audiology , psychology , medicine , clinical psychology , disease , psychiatry
Background: The differential diagnosis between Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) is challenging, justifying improvement of cognitive tools for use in clinical practice. Objective: To develop a new logarithm based on discriminative items of the ACE-R. Methods: The ACE-R was administered to 102 patients with mild dementia due to probable AD and 37 with mild probable bvFTD. Mokken scaling analysis was applied to identify the latent trait on the AD Group. Multivariate logistic regression and ROC curve analysis were carried out. Results: Mean total scores in ACE-R were 70.2 ± 10.8 in AD and 72.2 ± 11.1 in bvFTD. AD Mokken ACE-R (AMokACE-R) comprises 12 items measuring the same latent concept. Logistic regression with cross-validation pointed that AMokACE-R + Age + Sex-male + ACE-R subitems Orientation and Memory share importance as independent variables (p <0.05). The proposed logarithm reached an area under the curve of 0.922, with 88% sensitivity/specificity, 71% PPV and 96% NPV. Conclusion: The new logarithm using the ACE-R achieved high diagnostic accuracy in discriminating AD and bvFTD, showing superiority to previous findings. Further analysis in larger samples, with biomarkers or pathological confirmation, are necessary to confirm these findings.