Open AccessACCURACY OF FIGURE MEMORY TEST OF THE BRIEF COGNITIVE SCREENING BATTERY TO PREDICT AMYLOID STATUS IN OLDER ADULTS WITH SUBJECTIVE COGNITIVE DECLINE
Author(s) -
Adalberto Studart Neto,
Artur Martins Coutinho,
Camila de Godoi Carneiro,
Natália Cristina Moraes,
Mateus Rozalem Aranha,
Raphael Ribeiro Spera,
Jacy Bezerra Parmera,
Mônica Sanches Yassuda,
Sônia Maria Dozzi Brucki,
Cláudia C. Leite,
Carlos Alberto Buchpiguel,
Ricardo Nitríni
Publication year - 2021
Publication title -
dementia and neuropsychologia
Language(s) - English
Resource type - Conference proceedings
SCImago Journal Rank - 0.54
H-Index - 21
ISSN - 1980-5764
DOI - 10.5327/1980-5764.rpda011
Subject(s) - montreal cognitive assessment , medicine , cambridge neuropsychological test automated battery , cognition , receiver operating characteristic , neuropsychology , area under the curve , recall , cognitive decline , cognitive impairment , dementia , biomarker , audiology , neuropsychological test , psychology , disease , working memory , psychiatry , spatial memory , biochemistry , chemistry , cognitive psychology
Background: Some older adults with subjective decline (SCD) had a positive amyloid biomarker indicating a preclinical stage of Alzheimer’s disease. Objectives: To assess the accuracy of Delayed Recall of Figure Memory Test (DR-FMT) of Brief Cognitive Screening Battery to predict amyloid status in SCD older adults. Objective: To assess the accuracy of Delayed Recall of Figure Memory Test (DR-FMT) of Brief Cognitive Screening Battery to predict amyloid status in SCD older adults. Methods: The sample consisted of 45 older adults classified as SCD and 25 as controls without complaints (mean age of 76.4 and 73.5, respectively, p= 0.138). They were evaluated with BCSB and a standard neuropsychological battery (which includes MMSE, MoCA, RAVLT, Logical Memory and DR of Rey Complex Figure). Subjects underwent PIB-PET to assess their amyloid status and images were classified based on visual and semi-quantitative analyses with 3DSSP methodology. Results: Twelve SCD older adults (27.3%) had positive PIB-PET against six in the controls (23.1%). In SCD group, DR-FMT was the only memory test that correlated with SUV in amyloid PET (r = -0.514, p < 0.001). Only DR-FMT showed significant area under the curve (AUC) in the ROC curve in SCD older adults (AUC = 0.771, 95% CI 0.621 - 0.921). Among SCD older adults, DR-FMT < 8.0 had a sensitivity of 83.3%, a specificity of 68.7% and an accuracy of 72.7%. Conclusion: FMT proved to have a good sensitivity and accuracy to predict amyloid status in SCD older adults.