Open AccessThe relation between COVID-19 and cerebrovascular diseases
Author(s) -
Francisco Gabriel Cabral Oliveira,
Juliana Paiva Ribeiro Moura,
Matheus Henrique Mendes de Oliveira,
MYLENA TELES DE JESUS
Publication year - 2021
Language(s) - English
Resource type - Conference proceedings
DOI - 10.5327/1516-3180.740
Subject(s) - medicine , neuroprotection , antithrombotic , disease , pathophysiology , fibrinogen , thrombosis , tropism , receptor , intensive care medicine , bioinformatics , immunology , virus , biology
Covid-19 is characterized by respiratory syndrome and has symptoms that affect the central nervous system such as headache, anosmia, hypercoagulability, etc. In this sense, it is known that the virus shows tropism by the receptors of the angiotensin-converting enzyme 2 (ACE2), becoming a gateway to the neurological system, which can cause complications. Is to relate the infection by COVID-19 and the increase in cerebrovascular diseases. Methods: A literature review was carried out using search for scientific articles in PubMed, in April / 2021, with a filter in the last 5 years, using the descriptors “Covid”, “Cerebrovascular Diseases” and “Man” associated with the Boolean operator AND. Results: 53 articles were found, of which 19 were selected for research. There is a higher frequency of neurological symptoms in patients with COVID-19 than in patients without the disease. The effect of binding the virus to ACE2 receptors is to activate a cascade of cytokines, which tends to lead to serious complications. For this reason, severe coagulopathies can be caused, increasing products of the degradation of C-reactive protein, D Dimer, fibrinogen and thrombocytopenia. The increase in cerebrovascular events also occurs because the antithrombotic, neuroprotective, antihypertensive effects, among others, of the alternative renin-angiotensin system in the brain are interrupted due to COVID-19. Conclusion: It was seen that cerebrovascular events are related to the course of COVID-19, in which patients may develop several serious complications, such as encephalitis, strokes and vascular thrombosis. Thus, the pathophysiology of this disease is related to an inflammatory process.