Does hemorrhagic transformation in patients with ischemic stroke predict worse functional outcomes?

Background: Hemorrhagic transformation (HT) is a complication of stroke described as cause of early neurologic deterioration. Previous studies are discordant about the real impact of HT on stroke prognosis. Objectives: to describe the impact of HT in patient prognosis. Design and setting: Prospective cohort with acute ischemic stroke patients from a Stroke Unit, admitted between 2017 to 2020. Methods: All patients performed a brain computer tomography (CT) scan on their arrival and 24 hours later. Patients with or without HT were compared regarding functional 90-day outcome using the modified rankin scale (mRS). Functional disability was considered as mRS 2) [OR= 1,01; (IC95% 0,44–2,33) p= 0,987], when adjusted to age, sex, NIHSS, ASPECTS, trombolysis and other relevant variables. Conclusion: Although the occurrency of HT had been associated with worse short-term outcomes, patients seems to recover from disability over time.