Open AccessHemorrhagic stroke (ICH): A consequence of thromboembolic events resulting from COVID-19
Author(s) -
Guilherme Albuquerque de Araújo Costa,
Mariana Silva Regadas,
Myrela Murad Sampaio
Publication year - 2021
Language(s) - English
Resource type - Conference proceedings
DOI - 10.5327/1516-3180.364
Subject(s) - medicine , stroke (engine) , disseminated intravascular coagulation , d dimer , death toll , intensive care medicine , disease , inflammation , cytokine storm , cause of death , covid-19 , cardiology , infectious disease (medical specialty) , mechanical engineering , environmental health , engineering
The COVID-19 pandemic has been alarming the world since its first outbreak in December 2019. In this scenario, the presence of aggravating factors such as the elevation of the D-dimer and the reduction of the angiotensin-converting enzyme 2 (ACE2) during the clinical course of the disease, collaborated in the appearance of thromboembolic events derived from inflammatory processes and extensive intravascular coagulation, contributing to the emergence of diseases such as Hemorrhagic Stroke (ICH), leading the patient to have a worse clinical prognosis and a consecutive worsening of their health. Objective: To investigate occurrences of ICH derived from thromboembolic effects resulting from COVID-19. Methods: We selected 43 articles published between 2020 and 2021 on the PubMed platforms, SciELO portal, CAPES Journal and Google Scholar in order to conduct an integrative review within this database. Results: The elevated D-dimer was widely cited as a favorable factor for thromboembolic events due to the influence of excessive inflammatory processes, hypoxia and intravascular dissemination of coagulation, contributing to the development of ICH, given its greater association with disorders such as ischemic strokes, considering only these parameters. However, the reduction in ACE2 and the occurrence of cytokine storms end up causing increased inflammation and blood pressure, increasing the risk of stroke due to the rupture of capillaries sensitized by the action of thromboembolic effects and becoming a risk to the life and prognosis of patients infected with SARS-CoV2, especially in groups of individuals with a greater predisposition to the development of thromboembolic and hypertensive events related to COVID-19.