Open AccessEarly diagnosis of RelapsingRemitting Multiple Sclerosis: a review of the bibliography from 2016 to 2021
Author(s) -
Mariana Bastos Rodrigues dos Santos,
Felipe dos Santos Souza,
Pedro Felisberto Nogueira Viana Farah,
Yasmim Evelyn Lisboa Barbosa,
Felipe Oliveira Costa
Publication year - 2021
Language(s) - English
Resource type - Conference proceedings
DOI - 10.5327/1516-3180.203
Subject(s) - multiple sclerosis , disease , medicine , remyelination , cerebrospinal fluid , neuromyelitis optica , pathology , psychology , central nervous system , psychiatry , myelin
Background: Multiple Sclerosis (MS) is a neurodegenerative disease of the Central Nervous System (CNS), which damages myelin and axons by interrupting or reducing the flow of information. Early diagnosis of MS is essential to slow disease progression. The last review of the McDonald criteria, which organize the diagnosis of MS, took place in 2017 and it is necessary to understand the evidence that emerged in this period. Objectives: Review the updates of the bibliography published between 2016 and 2021. Design and setting: Bibliographic review made in Rio de Janeiro, Brazil. Methods: This research was made from Pubmed database search with the descriptors “Multiple Sclerosis Relapsing-Remitting” and “Early Diagnosis” and the filters “free full text”, “english”, “Portuguese”, “5 years”, “humans”. The discarded articles did not contemplate the entire theme in the design, content or quality of publication. Results: Patients with the first clinical event suggesting MS that meet the criteria for space dissemination may be diagnosed with relapsing-remitting multiple sclerosis (RRMS) when oligoclonal bands in the cerebrospinal fluid are detected, while other methods such as infrared spectroscopy and diffusion tensor tractography still show many concomitant signs among the varieties of MS. Conclusions: Cerebrospinal fluid analysis is the most sensitive criterion for early diagnosis of RRMS.