Open AccessMain Targets for Deep Brain Stimulation in Tourette Syndrome
Author(s) -
Cláudio Vinícius Araújo Pinheiro,
Thifanny Rodrigues de Oliveira
Publication year - 2021
Language(s) - English
Resource type - Conference proceedings
DOI - 10.5327/1516-3180.196
Subject(s) - tourette syndrome , deep brain stimulation , tics , basal ganglia , neuroscience , thalamus , globus pallidus , psychology , medicine , physical medicine and rehabilitation , psychiatry , central nervous system , disease , parkinson's disease
Tourette Syndrome (TS) is a neurodevelopmental disorder characterized by fast and recurrent vocal and motors tics, with classical onset in infancy. Psychotherapy and medicament are the treatments of choice, but as of lately the use of the Deep Brain Stimulation (DBS), still considered an experimental intervention, has shown promising results. Objective: Describe and analyze data regarding modern targets for DBS in TS. Methods: A narrative review was conducted. Research in the following databases was performed: MedLine, PubMed, Scielo. Criteria of inclusion were articles published between 2016 and 2021, selected according to relevancy and adequacy. Criteria of exclusion were non-pertinent articles. Results: Being TS a dysfunction in the Basal Ganglia and cortical-striatalthalamic-cortical circuit, it is thought to be in one those sites that DBS may present best results, nonetheless the precise optimal location it is still debatable and a myriad of targets have arisen. Recent studies showed the ideal target is likely the Internal Globus Pallidus, improving symptoms in 50%, followed by Centromedian parafascicular nucleus complex of Thalamus, with an improvement of 46.6%, measured by the Yale Global Tics Severity Scale (YGTSS). Conclusion: DBS is possible to become a gold standard treatment for TS with no improvement by the usual therapy, but larger studies showing the efficacy of new targets are still necessary.