Open Access5 giorni di antibiotico per le polmoniti non complicate sono sufficienti: i risultati di non inferiorità del SAFER RCT
Author(s) -
Gruppo di lettura di Reggio Emilia
Publication year - 2021
Publication title -
quaderni acp
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.144
H-Index - 5
eISSN - 2039-1382
pISSN - 2039-1374
DOI - 10.53141/peqacp.2021.5.n1
Subject(s) - medicine , amoxicillin , randomized controlled trial , pneumonia , safer , community acquired pneumonia , antibiotic therapy , intensive care medicine , surgery , antibiotics , computer security , computer science , microbiology and biotechnology , biology
5 days of antibiotic for uncomplicated pneumonia is enough: the non-inferiority results of the SAFER RCT The most important guidelines for the treatment of community-acquired pneumonia (CAP) indicate amoxicillin as the drug of first choice, however there is a lack of evidence-based indications about the duration of this therapy. This study conducted in 2 emergency departments in Canada randomized 281 children aged 6 months to 10 years with CAP without the need for hospitalization to treatment with high-dose amoxicillin for 5 days versus a traditional 10 day therapy. In terms of clinical recovery, both groups presented comparable results. In fact, the “per protocol” analysis, recommended for a “non-inferiority” design, did not formally provide this result. The exclusively clinical recruitment criteria (any investigations were optional), well reflect the reality of primary care, and the results, albeit with some limitations, suggest that in uncomplicated CAP, brief therapy should be considered in the guidelines.