Open AccessInterleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications
Author(s) -
Lili Magyari,
Dalma Várszegi,
Erzsébet Kövesdi,
Silvia Patrícia,
Bernadett Faragó,
Andras Javorhazy,
Katalin Sümegi,
Zsolt Bánfai
Publication year - 2014
Publication title -
world journal of orthopedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.76
H-Index - 43
ISSN - 2218-5836
DOI - 10.5312/wjo.v5.i4.516
Subject(s) - rheumatoid arthritis , medicine , disease , pathogenesis , immunology , interleukin , bioinformatics , precision medicine , personalized medicine , arthritis , cytokine , pathology , biology
Rheumatoid arthritis (RA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologic targets for RA treatment. The identification of disease-associated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics.