Factors predisposing to thrombosis after major joint arthroplasty | Zendy

Zoe Dailiana | Zendy; Nikolaos Stefanou | Zendy; Sokratis Varitimids | Zendy; Nikolaos Rigopoulos | Zendy; Apostolos Dimitroulias | Zendy; Theofilos Karachalios | Zendy; Κonstantinos Ν. Malizos | Zendy; Despoina Kyriakou | Zendy; Panagoula Κollia | Zendy

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Factors predisposing to thrombosis after major joint arthroplasty

Author(s) -

Zoe Dailiana,

Nikolaos Stefanou,

Sokratis Varitimids,

Nikolaos Rigopoulos,

Apostolos Dimitroulias,

Theofilos Karachalios,

Κonstantinos Ν. Malizos,

Despoina Kyriakou,

Panagoula Κollia

Publication year - 2020

Publication title -

world journal of orthopedics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.76

H-Index - 43

ISSN - 2218-5836

DOI - 10.5312/wjo.v11.i9.400

Subject(s) - fondaparinux , medicine , thrombosis , arthroplasty , low molecular weight heparin , antithrombin , osteoarthritis , anticoagulant , thrombophilia , heparin , surgery , pathology , alternative medicine , venous thromboembolism

Total joint arthroplasty is one of the most common options for end stage osteoarthritis of major joints. However, we must take into account that thrombosis after hip/knee arthroplasty may be related to mutations in genes encoding for blood coagulation factors and immune reactions to anticoagulants [heparin-induced thrombocytopenia (HIT)/thrombosis]. Identifying and characterizing genetic risk should help to develop diagnostic strategies or modify anticoagulant options in the search for etiological mechanisms that cause thrombophilia following major orthopedic surgery.

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