Open AccessFactors predisposing to thrombosis after major joint arthroplasty
Author(s) -
Zoe Dailiana,
Nikolaos Stefanou,
Sokratis Varitimids,
Nikolaos Rigopoulos,
Apostolos Dimitroulias,
Theofilos Karachalios,
Konstantinos N. Malizos,
Despoina Kyriakou,
Panagoula Κollia
Publication year - 2020
Publication title -
world journal of orthopedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.76
H-Index - 43
ISSN - 2218-5836
DOI - 10.5312/wjo.v11.i9.400
Subject(s) - fondaparinux , medicine , thrombosis , arthroplasty , low molecular weight heparin , antithrombin , osteoarthritis , anticoagulant , thrombophilia , heparin , surgery , pathology , alternative medicine , venous thromboembolism
Total joint arthroplasty is one of the most common options for end stage osteoarthritis of major joints. However, we must take into account that thrombosis after hip/knee arthroplasty may be related to mutations in genes encoding for blood coagulation factors and immune reactions to anticoagulants [heparin-induced thrombocytopenia (HIT)/thrombosis]. Identifying and characterizing genetic risk should help to develop diagnostic strategies or modify anticoagulant options in the search for etiological mechanisms that cause thrombophilia following major orthopedic surgery.