Open AccessOxysterols as promising small molecules for bone tissue engineering: Systematic review
Author(s) -
Ethan Cottrill,
Julianna L. Lazzari,
Zach Pennington,
Jeff Ehresman,
Andrew Schilling,
Naomi Dirckx,
Nicholas Theodore,
Daniel M. Sciubba,
Timothy F. Witham
Publication year - 2020
Publication title -
world journal of orthopedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.76
H-Index - 43
ISSN - 2218-5836
DOI - 10.5312/wjo.v11.i7.328
Subject(s) - oxysterol , medicine , in vivo , bone formation , bioinformatics , systematic review , medline , cholesterol , biology , microbiology and biotechnology , biochemistry
Bone tissue engineering is an area of continued interest within orthopaedic surgery, as it promises to create implantable bone substitute materials that obviate the need for autologous bone graft. Recently, oxysterols - oxygenated derivatives of cholesterol - have been proposed as a novel class of osteoinductive small molecules for bone tissue engineering. Here, we present the first systematic review of the in vivo evidence describing the potential therapeutic utility of oxysterols for bone tissue engineering.