Open AccessInvestigational growth factors utilized in animal models of spinal fusion: Systematic review
Author(s) -
Ethan Cottrill,
A. Karim Ahmed,
Noah L Lessing,
Zach Pennington,
Wataru Ishida,
Alexander PerdomoPantoja,
Sheng Fu L. Lo,
Elizabeth Howell,
Christina Holmes,
C. Rory Goodwin,
Nicholas Theodore,
Daniel M. Sciubba,
Timothy F. Witham
Publication year - 2019
Publication title -
world journal of orthopedics
Language(s) - English
Resource type - Journals
ISSN - 2218-5836
DOI - 10.5312/wjo.v10.i4.176
Subject(s) - medicine , spinal fusion , iliac crest , systematic review , bioinformatics , medline , surgery , political science , law , biology
Over 4 Americans annually undergo spinal fusion surgeries, yet up to 40% of these procedures result in pseudoarthrosis even with iliac crest autograft, the current "gold standard" treatment. Tissue engineering has the potential to solve this problem via the creation of bone grafts involving bone-promoting growth factors ( e.g ., bone morphogenetic protein 2). A broad assessment of experimental growth factors is important to inform future work and clinical potential in this area. To date, however, no study has systematically reviewed the investigational growth factors utilized in preclinical animal models of spinal fusion.