Open AccessFluoxetine induces cytotoxic endoplasmic reticulum stress and autophagy in triple negative breast cancer
Author(s) -
Michelle Bowie,
Patrick G. Pilié,
Julia Wulfkuhle,
Siya Lem,
A Hoffman,
Shraddha Desai,
Emanuel F. Petricoin,
Amira Carter,
Adrian Ambrose,
Victoria L. Seewaldt,
Dihua Yu,
Catherine Ibarra Drendall
Publication year - 2015
Publication title -
world journal of clinical oncology
Language(s) - English
Resource type - Journals
ISSN - 2218-4333
DOI - 10.5306/wjco.v6.i6.299
Subject(s) - endoplasmic reticulum , unfolded protein response , autophagy , microbiology and biotechnology , protein kinase a , pi3k/akt/mtor pathway , cell growth , cell cycle , programmed cell death , biology , kinase , signal transduction , cell , apoptosis , biochemistry
To investigate the mechanism of action of lipophilic antidepressant fluoxetine (FLX) in representative molecular subtypes of breast cancer.