Open AccessTargeted immunotherapy for non-small cell lung cancer
Author(s) -
Monali Vasekar,
Xin Liu,
Hong Zheng,
Chandra P. Belani
Publication year - 2014
Publication title -
world journal of clinical oncology
Language(s) - Uncategorized
Resource type - Journals
ISSN - 2218-4333
DOI - 10.5306/wjco.v5.i2.39
Subject(s) - medicine , immunotherapy , ipilimumab , lung cancer , nivolumab , oncology , adverse effect , targeted therapy , melanoma , immune system , cancer immunotherapy , cancer , immunology , cancer research
Targeted therapies that deliver the expected anti-tumor effects while mitigating the adverse effects are taking the cancer world by storm. The need for such therapies in non-small cell lung cancer (NSCLC), where systemic cytotoxic chemotherapies still remain the backbone of management, is felt more than ever before. Runway success of immunotherapies such as Ipilimumab for melanoma has brought excitement among oncologists. Immune-based treatments are in various stages of evaluation for NSCLC as well. Immunotherapies using strategies of antigen based or cell based vaccines, and blocking immune checkpoints are of substantial interest. Meaningful clinical responses are yet to be reaped from these new treatment modalities.