Open AccessBone metastases: When and how lung cancer interacts with bone
Author(s) -
Ilaria Roato
Publication year - 2014
Publication title -
world journal of clinical oncology
Language(s) - English
Resource type - Journals
ISSN - 2218-4333
DOI - 10.5306/wjco.v5.i2.149
Subject(s) - medicine , lung cancer , bone metastasis , immune system , lung , metastasis , cancer , pathology , cancer cell , disease , cancer research , immunology
BONE METASTASIS IS A COMMON AND DEBILITATING CONSEQUENCE OF LUNG CANCER: 30%-40% of patients with non-small cell lung cancer develop bone metastases during the course of their disease. Lung cancer cells find a favorable soil in the bone microenvironment due to factors released by the bone matrix, the immune system cells, and the same cancer cells. Many aspects of the cross-talk among lung tumor cells, the immune system, and bone cells are not clear, but this review aims to summarize the recent findings in this field, with particular attention to studies conducted to identify biomarkers for early detection of lung cancer bone metastases.