Open AccessTumor specifically internalizing peptide ‘HN-1’: Targeting the putative receptor retinoblastoma-regulated discoidin domain receptor 1 involved in metastasis
Author(s) -
Frank D. Hong,
Miguel Castro,
Klaus D. Linse
Publication year - 2022
Publication title -
world journal of clinical oncology
Language(s) - English
Resource type - Journals
ISSN - 2218-4333
DOI - 10.5306/wjco.v13.i5.323
Subject(s) - ddr1 , discoidin domain , cancer research , receptor , biopanning , phage display , peptide , immunohistochemistry , medicine , metastasis , peptide library , biology , microbiology and biotechnology , pathology , cancer , peptide sequence , biochemistry , receptor tyrosine kinase , gene
Less than 0.5% of intravenously injected drugs reach tumors, contributing to side effects. To limit damage to healthy cells, various delivery vectors have been formulated; yet, previously developed vectors suffer from poor penetration into solid tumors. This issue was resolved by the discovery of HN-1 peptide isolated via biopanning a phage-display library. HN-1 targets human head and neck squamous cell carcinoma (HNSCC) (breast, thyroid; potentially lung, cervix, uterine, colon cancer), translocates across the cell membrane, and efficiently infiltrates solid tumors. HN-1 peptide has been conjugated to various anticancer drugs and imaging agents though the identity of its receptor remained enigmatic.