Open AccessGastric cancer molecular classification based on immunohistochemistry and in situ hybridization: Analysis in western patients after curative-intent surgery
Author(s) -
Marcus Fernando Kodama Pertille Ramos,
Marina Alessandra Pereira,
Evandro Sobroza de Mello,
Cinthya dos Santos Cirqueira,
Bruno Zilberstein,
Venâncio Avancini Ferreira Alves,
Ulysses Ribeiro-Júnior,
Cristina Ivan
Publication year - 2021
Publication title -
world journal of clinical oncology
Language(s) - English
Resource type - Journals
ISSN - 2218-4333
DOI - 10.5306/wjco.v12.i8.688
Subject(s) - medicine , immunohistochemistry , cancer , in situ hybridization , cancer surgery , surgery , pathology , gene expression , gene , biology , biochemistry
Gastric cancer (GC) is a highly heterogeneous disease, and the identification of molecular subtyping of gastric adenocarcinoma emerged as a promising option to define therapeutic strategies and prognostic subgroups. However, the costs and technical complexity of molecular methodologies remains an obstacle to its adoption, and their clinical significance by other approaches needs further evidence.