Open AccessLong-term complete response in metastatic poorly-differentiated neuroendocrine rectal carcinoma with a multimodal approach: A case report
Author(s) -
S. Della Torre,
Germana de Nucci,
Pietro Maria Lombardi,
Samuele Grandi,
Gianpiero Manes,
R. Bollina
Publication year - 2021
Publication title -
world journal of clinical oncology
Language(s) - English
Resource type - Journals
ISSN - 2218-4333
DOI - 10.5306/wjco.v12.i6.500
Subject(s) - medicine , rectal carcinoma , neuroendocrine carcinoma , term (time) , multimodal therapy , colorectal cancer , oncology , carcinoma , cancer research , surgery , cancer , physics , quantum mechanics
Neuroendocrine gastrointestinal tumors (NETs) are rare and have different natural behaviors. Surgery is the gold standard treatment for local disease while radiotherapy has been demonstrated to be ineffective. Poorly differentiated neuroendocrine carcinomas (NECs) represent only 5%-10% of digestive NETS. Due to aggressive growth and rapid metastatic diffusion, early diagnosis and a multidisciplinary approach are mandatory. The role of surgery and radiotherapy in this setting is still debated, and chemotherapy remains the treatment of choice.