Open AccessUptake and outcomes of small intestinal and urinary tract cancer surveillance in Lynch syndrome
Author(s) -
Jeshua DeJesse,
Ravy K. Vajravelu,
Christina Dudzik,
Gillain Constantino,
Jessica M. Long,
Kirk J. Wangensteen,
Kathleen D Valverde,
Bryson W. Katona
Publication year - 2021
Publication title -
world journal of clinical oncology
Language(s) - English
Resource type - Journals
ISSN - 2218-4333
DOI - 10.5306/wjco.v12.i11.1023
Subject(s) - medicine , lynch syndrome , cancer , referral , colorectal cancer , mlh1 , gastrointestinal cancer , family medicine , dna mismatch repair
Lynch syndrome (LS) is a hereditary cancer predisposition syndrome associated with increased risk of multiple cancers. While colorectal cancer surveillance decreases mortality in LS and is recommended by guidelines, there is lack of evidence for the efficacy of surveillance for extra-colonic cancers associated with LS, including small intestinal cancer (SIC) and urinary tract cancer (UTC). Given the limited evidence, guidelines do not consistently recommend surveillance for SIC and UTC, and it remains unclear how often individuals will choose to undergo and follow through with extra-colonic surveillance recommendations.