Open AccessA biomarker study in Peruvian males with breast cancer
Author(s) -
Carlos A. Castañeda,
Miluska Castillo,
Luis A. Bernabe,
Joselyn Sanchez,
Ebert Torres,
Nancy Suárez,
Katherine Tello,
Hugo Fuentes,
Jorge Dunstan,
Miguel De La Cruz,
José M. Cotrina,
Julio Abugattas,
Henry Guerra,
Henry Gómez
Publication year - 2021
Publication title -
world journal of clinical oncology
Language(s) - English
Resource type - Journals
ISSN - 2218-4333
DOI - 10.5306/wjco.v12.i10.926
Subject(s) - medicine , breast cancer , biomarker , oncology , estrogen receptor , pathological , male breast cancer , androgen receptor , cancer , intraclass correlation , immunohistochemistry , population , pathology , biology , prostate cancer , clinical psychology , biochemistry , environmental health , psychometrics
Breast cancer (BC) frequency in males is extremely low and tumor features vary from its female counterpart. Breast cancer clinical and pathological features differ by race in women. Tumor infiltrating lymphocyte (TIL) levels, mismatch repair (MMR) protein loss, androgen receptor (AR) expression, and PIK3CA gene mutations are predictive biomarkers of response to biological therapy in female BC. There is limited information about clinical and pathological features as well as predictive biomarkers in males of non-Caucasian races with BC.