Open AccessMutational analysis ofRashotspots in patients with urothelial carcinoma of the bladder
Author(s) -
Kiran Tripathi,
Apul Goel,
Atin Singhai,
Minal Garg
Publication year - 2020
Publication title -
world journal of clinical oncology
Language(s) - English
Resource type - Journals
ISSN - 2218-4333
DOI - 10.5306/wjco.v11.i8.614
Subject(s) - gene , point mutation , exon , coding region , bladder cancer , polymerase chain reaction , single nucleotide polymorphism , microbiology and biotechnology , gene isoform , cancer research , restriction fragment length polymorphism , biology , medicine , mutation , genetics , cancer , genotype
Mutational activation of Ras genes is established as a prognostic factor for the genesis of a constitutively active RAS-mitogen activated protein kinase pathway that leads to cancer. Heterogeneity among the distribution of the most frequent mutations in Ras isoforms is reported in different patient populations with urothelial carcinoma of the bladder (UCB).