Open AccessUpdates on “Cancer Genomics and Epigenomics”
Author(s) -
Aarti Sharma,
Kiran Sharma,
Cherry Bansal,
Ashok Kumar
Publication year - 2020
Publication title -
world journal of clinical oncology
Language(s) - English
Resource type - Journals
ISSN - 2218-4333
DOI - 10.5306/wjco.v11.i11.890
Subject(s) - epigenomics , epigenetics , genomics , dna methylation , computational biology , chromatin , cancer , personalized medicine , epigenesis , epigenome , genome , bioinformatics , genetics , biology , medicine , gene , gene expression
The field of "Cancer Genomics and Epigenomes" has been widely investigated for their involvement in cancer to understand the basic processes of different malignancies. The aggregation of genetic and epigenetic alterations also displays a wide range of heterogeneity making it quite necessary to develop personalized treatment strategies. The complex interplay between DNA methylation and chromatin dynamics in malignant cells is one of the major epigenetic mechanisms that lead to gene activation and repression. Hence, each tumor needs to be fully characterized to satisfy the ideas of personalized treatment strategies. The present article addresses various aspects of genome characterization methods and their potential role in the field of cancer genomics and epigenomics.