Open AccessTrends in TC/HDL and LDL/HDL Ratios across the Age Span: Data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES)
Author(s) -
Inga Wang,
Jay Kapellush,
Stephen Hou,
Mohammad Hifz Ur Rahman,
Xiaoyan Li,
David G. Ritchie
Publication year - 2021
Publication title -
asian journal of complementary and alternative medicine
Language(s) - English
Resource type - Journals
ISSN - 2347-3894
DOI - 10.53043/2347-3894.acam90002
Subject(s) - national health and nutrition examination survey , medicine , triglyceride , cholesterol , high density lipoprotein , demography , endocrinology , population , environmental health , sociology
Background. Cholesterol levels in total cholesterol (TC), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and triglyceride (TG) contribute to atherosclerosis and its clinical consequences. Objectives. This study aimed to examine the trends in serum TC/HDL and LDL/HDL ratio across the age span. Methods. This is an observational study. Blood lipid measurements, taken from 85,646 noninstitutionalized participants, aged 6 to 80, were obtained from the National Health and Nutrition Examination Survey (NHANES) study. We compared the TC/HDL and LDL/HDL ratio trends in three distinct cross-sectional surveys during 2007-2010, 2011-2014, and 2015- 2018. Results. Cholesterol ratios changed by age and differed by sex. Mean TC/HDL ratios declined from 4.03 (95% CI, 4.01-4.05) in 2007-2010, to 3.84 (95% CI, 3.81-3.87) in 2015-2018 (p<.05 for linear trend) in male; mean TC/HDL ratios declined from 3.69 (95% CI, 3.67-3.70) in 2007- 2010, to 3.45 (95% CI, 3.42-3.47) in 2015-2018 (p<.05 for linear trend) in female. Mean LDL/HDL ratios declined from 2.30 (95% CI, 2.28-2.32) in 2007-2010, to 2.18 (95% CI, 2.15- 2.20) in 2015-2018 (p<.05 for linear trend) in male; mean LDL/HDL ratios declined from 2.04 (95% CI, 2.02-2.06) in 2007-2010, to 1.96 (95% CI, 1.94-1.98) in 2015-2018 (p<.001 for linear trend) in female. Conclusions. Between 2007 and 2018, favorable trends in lipid ratio levels were observed among noninstitutionalized residents in the US.