Open AccessFormulation and Optimization of Ciprofloxacin Hydrochloride 500mg Floating Tablets
Author(s) -
Sara Anas S.K,
Abd ElKarim M.A.K.,
Eltayeb Suliman E,
Salah Mohamed Elhasan
Publication year - 2022
Language(s) - English
DOI - 10.52981/ojps.v2i2.2201
Subject(s) - ciprofloxacin hydrochloride , sodium bicarbonate , lubricant , materials science , lag time , polymer , chemical engineering , chromatography , composite material , chemistry , ciprofloxacin , organic chemistry , biochemistry , biological system , biology , engineering , antibiotics
Floating tablets of ciprofloxacin Hydrochloride was formulated as controlled gas powder system (CGPS) firstly by dry method which is found to by not suitable for bad micrometric properties of the powder bed, so these properties were improved by wet massing off powder using isopropanole as granulating liquid. The floating lag time (FLT) and total floating time (TFT) and release rate were optimized by different trials namely using the binder poly vinyl pyrelidone (PVP) in solution form, increasing the hydrophobic lubricant used, substitution of viscolyzing agent by other polymers, and then increasing its percentage and finally increasing percentage of viscolyzing components, PVP, sodium bicarbonate and the total tablet weight. The formula of the last step was of the best properties.