Open AccessThe prognostic efficacy of beta2-microglobulin in acute pulmonary embolism
Author(s) -
Sotirios Kakavas,
Aggeliki Papanikolaou,
Evangelos Balis,
Evgenios Metaxas,
Giorgos Tatsis
Publication year - 2017
Publication title -
acute medicine
Language(s) - English
Resource type - Journals
eISSN - 1747-4892
pISSN - 1747-4884
DOI - 10.52964/amja.0655
Subject(s) - medicine , pulmonary embolism , prospective cohort study , beta 2 microglobulin , risk stratification , multivariate analysis , white blood cell , c reactive protein , inflammation
Our aim was to prospectively assess the prognostic value of beta2- microglobulin (b2-M) in patients with acute pulmonary embolism (PE). We conducted a prospective study of 109 patients admitted in a pulmonary clinic due to acute PE. A panel of inflammatory markers including b2-M white blood cell (WBC) count and C-reactive protein (CRP) was determined for each patient. In this preliminary study, baseline b2-M levels significantly correlated with the impairment of oxygenation and with all the parameters that are used for the early risk stratification of patients. In multivariate analysis, patients’ age and baseline b2-M levels were significantly associated with an increased risk of death. These findings require further prospective validation.