Open AccessThe Diagnostic and Prognostic Role of Serum MicroRNAs in Ovarian Cancer
Author(s) -
Ming Yin,
Aiping Chen
Publication year - 2018
Publication title -
journal of biology and life science
Language(s) - English
Resource type - Journals
ISSN - 2157-6076
DOI - 10.5296/jbls.v9i2.13551
Subject(s) - ovarian cancer , microrna , oncology , stage (stratigraphy) , medicine , cancer , clinical diagnosis , drug resistance , biology , intensive care medicine , gene , paleontology , biochemistry , microbiology and biotechnology
AimSummarize the research progress of serum miRNAs in clinical application for early diagnosis and prognosis of ovarian cancer. MethodsReview of the recently published literature these was conducted. We selected reviews and clinical researches from different scientific societies.ResultsThe abnormal expression of serum miRNAs has a certain clinical value in theearly diagnosis of ovarian cancer. Many miRNAs, which are involved in regulating ovarian cancer cell growth, migration, and drug resistance, are also closely related to the patients’ survival rate and affect the prognostic condition of the patients. So the serum miRNAs may be useful diagnostic and prognostic biomarkers.Conclusions Studies have shown that serum miRNAs has the tumor specificity and high stability, enabling it has the potential for early diagnosis, prognosis and sensitivity to chemotherapy. However, the researches on serum miRNAs is still at the primary stage, further researches is needed for application of serum miRNAs in early diagnosis and prognosis of ovarian cancer.