Open AccessComprehensive Analysis of TGF β & β – Catenin Components in Various Human Cancer Tissues
Author(s) -
Jamila Sameer Daraghmeh,
Bayan Mansour,
Asmaa Yousef Kmail,
Iqab Daraghmeh
Publication year - 2021
Publication title -
journal of applied biotechnology
Language(s) - English
Resource type - Journals
ISSN - 2327-0640
DOI - 10.5296/jab.v9i1.18354
Subject(s) - signal transduction , pi3k/akt/mtor pathway , cancer research , wnt signaling pathway , catenin , protein kinase b , cancer , transforming growth factor , biology , computational biology , microbiology and biotechnology , genetics
Studies over the last years revealed significant insights into the β-Catenin & TGF β signal transduction pathways and that such pathways are abnormal activated in abundant cancer types. According to the straight forward effect of these pathways in various tumor types, both pathways are currently considered targets for innovative cancer therapies. This view study emphasizes 13 proteins that are implicated in these two pathways. As there has been widespread research into the proteins that involved in these pathways, we have utilized data existing in the Human Protein Atlas database in this paper to examine the expression of 53 crucial proteins that are recognized to be involved in the activation of these pathways in a distinct group of 45 cancer types. Our findings revealed notably that the proteins (SKIL, SHC, ERK1/2, RAS, PI3K (PIK3CA), SMAD8, ACVR2A/1B SNON, AKT, and SMAD3, from TGF β and (RNF43, SNAIL1 and DVl) for β catenin show high expression in most caner tissues. Our results strongly suggest that these proteins might have the ability to act as potential objects for remedies and provide perception into the molecular basis of cancer.