Open AccessPulverized Mangifera indica (Mango) Seed-kernel Modulated Serum Lipid Profile in Monosodium Glutamate-challenged Rats
Author(s) -
Anthony Cemaluk C. Egbuonu,
Gladys A. Ekwuribe
Publication year - 2017
Publication title -
journal of applied biotechnology
Language(s) - English
Resource type - Journals
ISSN - 2327-0640
DOI - 10.5296/jab.v5i2.11649
Subject(s) - monosodium glutamate , chemistry , mangifera , hyperlipidemia , tannin , high density lipoprotein , lipid profile , cholesterol , medicine , endocrinology , biochemistry , food science , biology , botany , diabetes mellitus
Mangifera indica seed kernel was assessed for antinutirent content and effects on serum lipid profile of monosodium glutamate-challenged rats. Group A rats received 8000 mg/kg body weight, b.w of monosodium glutamate (MSG). Group B rats received the sample extract (300 mg/kg b.w). Group C rats were sham-administered distilled water. Groups D and E rats received 8000 mg/kg b.w of MSG in addition to 200 and 400 mg/kg b.w, respectively of sample extract. Tannin (29.21±5.39 mg/100 g) was highest (p<0.05) while phytate (0.38±0.02 mg/100g) was least. After fourteen days daily oral exposure, MSG-exposed rats had higher (p<0.05) total cholesterol (CHOL), triacylglycerol (TAG) and low density lipoprotein (LDL) but lower (p<0.05) high density lipoprotein (HDL) concentration compared to rats in the other groups. MSG-intoxicated rats co-treated respectively with 200 and 400 mg/kg b.w of the extract had dose dependent reduction (p<0.05) compared to the corresponding effects in non-extract-co-treated MSG-intoxicated rats. Compared to others, rats in the Extract group had higher (p<0.05) CHOL: TAG but lower (p<0.05) TAG:CHOL ratios while rats in the MSG-group had higher (p<0.05) HDL:LDL but lower (p<0.05) LDL:HDL ratios. Results demonstrated the preponderance of tannin in, and significant serum lipid lowering potential in normal and MSG-challenged rats of, the sample. Studies using antinutrient-process-reduced sample in hyperlipidemia-related health-challenged models and collaborating the suggested implication of lipid-profile-component-ratios are warranted and recommended.