Vaccination of pentivalent, DTP, ADS vaccine for healthy and frequently sick children

Aim . To study the formation of anti-diphtheria post-vaccination immunity in practically healthy, and frequently sick children vaccinated with pentavalent, ADTP, and ADT vaccine. Material and methods . We observed 50 practically healthy and 92 frequently sick children. All children were vaccinated three times with a pentavalent vaccine, as well as revaccination with ADTP and ADT. The formation of specific anti-diphtheria immunity was detected for all children after 6 months, after 1 year, and after 5 years. The results were interpreted according to the final value of the optical density levels of protection: basic from -0,01 to 0,1; full protection -> 0.1; long-term protection -> 1.0. Results and discussion . After 6 months the intensity of post-vaccination immunity in both practically healthy and frequently sick children was the highest: full protection (> 0.1) (45,8%), basic protection (0,01 to 0,1) (31,0%). Statistical significance decreased after a year: full protection (45,8% versus 12,1%, p <0,001), and lack of protection increased (2,6% versus 55,7%, p <0,001), which indicated to the development of unstable immunity, therefore revaccination with ADTP and ADT vaccines were performed. 5 years after revaccination specific immunity tended to increase in both healthy and often-ill children. Conclusion . To create stable and long-term immunity when using “killed” vaccines and toxoids, revaccination vaccinations are required at various times after the course of vaccination for frequently ill children, as indicated by the data of basic and complete protection.