Open AccessThe study of acute and subchronic toxicities of Da Dai Trang HVD capsules in experimental animals
Author(s) -
Pham Thi Van Anh,
Nguyen Van Dam,
Phạm Thanh Kỳ,
Vu Viet Hang,
Dinh Thi Thu Hang
Publication year - 2021
Publication title -
nghiên cứu y học
Language(s) - English
Resource type - Journals
ISSN - 2354-080X
DOI - 10.52852/tcncyh.v148i12.773
Subject(s) - medicine , acute toxicity , toxicity , pharmacology , oral administration , dose dependence , oral dose , traditional medicine
The purpose of this research is to evaluate the acute and subchronic toxicities of DA DAI TRANG HVD capsules through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO and OECD in Wistar rats with oral doses of 1.44 g/kg/day (equal to recommended human dose) and 4.32 g/kg/day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, DA DAI TRANG HVD capsules at the highest dose used for mice (99.9 g materials/kg) did not express acute toxicity in mice. In term of the subchonic toxicity test, DA DAI TRANG HVD had no deleterious effect on hematological parameters, hepato-renal functions, macroscopic and microscopic images of livers and kidneys of rats. In conclusion, DA DAI TRANG HVD capsules did not produce the acute and subchronic toxicities in Swiss mice and Wistar rats.