Open AccessThe evaluation of acute and subchronic toxicities of An Phu Khang capsules in experimental animals
Author(s) -
Ha Thi Yen,
Trần Thanh Tùng,
Dang Thi Thu Hien
Publication year - 2021
Publication title -
nghiên cứu y học
Language(s) - English
Resource type - Journals
ISSN - 2354-080X
DOI - 10.52852/tcncyh.v148i12.615
Subject(s) - acute toxicity , toxicity , medicine , pharmacology , oral administration , kidney , oral dose , median lethal dose
The purpose of this research was to evaluate the acute and subchronic toxicities of An Phu Khang capsules through oral administration in experimental animals. The acute toxicity was determined by the method of Litchfield Wilcoxon in Swiss mice. The subchronic toxicity was evaluated by the recommendation of WHO in Wistar rats at these doses of 0.54 g/kg b.w/day (equal to recommended human dose) and 1.62 g/kg b.w/day (3 times as high as recommended human dose) in 4 consecutive weeks. As a result, An Phu Khang capsules at the highest dose used for mice (36.29 g/kg b.w) did not show acute toxicity in mice. In terms of the subchronic toxicity test, after oral administration of An Phu Khang capsules, hematological parameters, hepato-renal functions, and microscopic images of liver and kidney at both doses were unchanged compared with the control group. In conclusion, An Phu Khang with both doses 0.54 g/kg b.w/day and 1.62 g/kg b.w/day did not produce acute and subchronic toxicities in Swiss mice and Wistar rats.