Open AccessALKYL-1H-BENZO[D]IMIDAZOLE SYNTHESIS FROM ALKYL BROMIDES AND 1,2-BENZENEDIAMINES BY A MILD DOMINO REACTION
Author(s) -
George Brătulescu
Publication year - 2021
Publication title -
annals of the university of craiova series chemistry
Language(s) - English
Resource type - Journals
eISSN - 2821-4471
pISSN - 1223-5288
DOI - 10.52846/aucchem.2021.2.01
Subject(s) - alkyl , domino , chemistry , imidazole , reagent , halide , pyridine , catalysis , solvent , organic chemistry , medicinal chemistry , combinatorial chemistry , polymer chemistry
A method was implemented for synthesis of 2-alkyl-1H-benzo[d]imidazole derivatives in dry medium. Starting reagents, 1,2-diaminobenzene derivatives and primary alkyl halides using pyridine N-oxide is converted into benzimidazoles. The protocol does not use catalyst and solvent. Simplicity and easy work-up are the important advantages of the method.
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