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SIMULTANEOUS ESTIMATION OF RABEPRAZOLE SODIUM AND ACECLOFENAC COMBINED CAPSULE DOSAGE FORM AS PER ICH GUIDELINE BY UV SPECTROSCOPIC METHODS
Author(s) -
Arunoday Kumar Prajapati Ashok Patel
Publication year - 2017
Publication title -
zenodo (cern european organization for nuclear research)
Language(s) - English
DOI - 10.5281/zenodo.268626
Subject(s) - aceclofenac , capsule , rabeprazole , guideline , sodium , chemistry , chromatography , medicine , pharmacology , organic chemistry , omeprazole , biology , botany , pathology
The present work aimed to develop and validate spectrophotometric methods for simultaneous estimation of rabeprazole sodium and aceclofenac in a pure and capsule dosage form. A simple, sensitive, spectrophotometric method in UV region has been developed for the simultaneous estimation of Rabeprazole sodium and Aceclofenac in bulk and semi dosage form (Capsule). Standard solution of Rabeprazole sodium shows maximum absorbance at 283 nm and Aceclofenac shows maximum absorbance at 276 nm. Beer’s Lamberts law is obeyed in concentration range 10-60 µg/ml for Rabeprazole with regression, slope and intercept of 0.991, 0.0918 and 0 respectively while for, Beer’s Aceclofenac Lambert law is obeyed in concentration range 10-60 µg/ml with regression, slope and intercept having 0.9984, 0.2069 and 0.0253 respectively. Method was validated for linearity, range, accuracy, precision, recovery studies and interference study of mixture. All these parameters showed the adaptability of the method for the quality control analysis of the drug in bulk and in combination formulations. Keywords: Rabeprazole sodium, Aceclofenac, Simultaneous equations, absorbance interference stud

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