Open AccessIMMUNOHISTOCHEMICAL EXPRESSION OF P53 IN ORAL SQUAMOUS CELL CARCINOMA, ORAL EPITHELIAL PRECURSOR LESIONS, AND NORMAL ORAL MUCOSA
Author(s) -
Abbas Saleem Khan,
Shahzad Ahmad,
Fatima Iqbal,
Abdus Saboor,
Muhammad Nisar,
Tehmiushin,
Ahmareen Khalid Sheikh,
Mohsina Haq,
Tariq Ahmad,
Basheer Rehman
Publication year - 2022
Publication title -
journal of medical sciences
Language(s) - English
Resource type - Journals
eISSN - 1997-3446
pISSN - 1997-3438
DOI - 10.52764/jms.21.29.4.9
Subject(s) - medicine , oral mucosa , immunohistochemistry , malignancy , pathology , basal cell , oral and maxillofacial pathology , biomarker , carcinoma , epithelium , dentistry , biology , biochemistry
Objective: To assess the immunohistochemical expression of p53 in tissue samples of oral squamous cell carcinoma (OSCC), oral epithelial precursor lesions and normal oral mucosa.
Methods: A comparative cross-sectional study was jointly conducted at the Departments of Pathology and Oral and Maxillofacial Surgery of various medical and dental institutes of the country from April 2016 to March 2017. A total of 180 subjects were included in the study. Oral tissue specimens were collected for lab investigations after obtaining written consent from all subjects. TP53 was assessed by means of immunohistochemistry in tissue samples of 60 cases of OSCC, 60 cases of epithelial precursor lesions and normal oral mucosal samples of 60 healthy individuals. Data was recorded, evaluated and analysed by SPSS version 20.
Results: p53 protein expression was noted in 85% OSCC and 73% oral epithelial precursor lesions. Among healthy individuals ,one subject showed p53 immunoreactivity in normal oral mucosa.
Conclusion: Raised TP53 overexpression in OSCC and oral precursor lesions, compared to normal oral mucosa make it a probable candidate for potential predictive biomarker in oral premalignancy and malignancy.