Open AccessFormulation, Physical Characterization and Antioxidant Potential of Silymarin Suspensions and Emulsions
Author(s) -
Arooj Amna,
Nazish Jahan,
Khalil Ur Rehman,
Zille Huma
Publication year - 2021
Publication title -
pakistan journal of scientific and industrial research. series a: physical sciences
Language(s) - English
Resource type - Journals
eISSN - 2223-2559
pISSN - 2221-6413
DOI - 10.52763/pjsir.phys.sci.64.3.2021.247.253
Subject(s) - xanthan gum , pulmonary surfactant , tragacanth , bioavailability , chemistry , polyethylene glycol , chromatography , emulsion , gum arabic , gum acacia , food science , organic chemistry , materials science , rheology , biochemistry , composite material , bioinformatics , biology
Silymarin, is a therapeutically important flavonoid act as a hepatoprotective agent. However, has a positive effect on metabolism act as a hydrophobic drug but has a very low bioavailability. The aim of the present study was to prepare appropriate formulations of Silymarin in order to enhance its bioavailability. The natural suspending agents like (Xanthan gum, Tragacanth gum, Acacia gum and Iranian gum) were used for the formulation of suspensions, while emulsions were prepared with the combination of surfactant, co-surfactant and oil. The formulations were evaluated for their physical stability, pH, refractive index and conductivity. Among different formulations and suspensions prepared with xanthan gum as a green stabilizing agents were most stable. Emulsions formulated with tween 80 as a surfactant, polyethylene glycol as co-surfactant and olive oil were clear and stable for more than six months. The refractive index, pH and conductivity of the most stable suspension and emulsions were 1.347, 6.9 and 0.18 s/m and 1.43, 6.9, 0.01 s/m respectively. It was concluded that xanthan gum and tween 80 with polyethylene glycol has a good potential to enhance the therapeutic efficiency and stability of silymarin suspension and emulsion.