Open AccessAntiplasmodial Activity of Methanolic Extract of Asparagus officinalis L. Stem on Plasmodium berghei Infected Mice
Author(s) -
J. B. Minari,
A. A. Odutuga,
Fisayo Abraham Bamisaye,
Leye Jonathan Babatola
Publication year - 2016
Publication title -
pakistan journal of scientific and industrial research. series b: biological sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.117
H-Index - 5
eISSN - 2223-2567
pISSN - 2221-6421
DOI - 10.52763/pjsir.biol.sci.59.2.2016.99.104
Subject(s) - mean corpuscular hemoglobin concentration , plasmodium berghei , officinalis , phytochemical , hemoglobin , mean corpuscular hemoglobin , mean corpuscular volume , biology , terpenoid , traditional medicine , glycoside , pharmacology , chemistry , botany , biochemistry , malaria , medicine , immunology
This study aims at investigating the antiplasmodial activity of methanolic extract of Asparagusofficinalis L. stem on Plasmodium berghei infected mice. To investigate this, the mice were infected withP.berghei to cause malaria. The mice were simultaneously given oral doses (20, 40 and 60 mg/kg bodyweight) of methanolic extract of A. officinalis L. stem. The phytochemical constituents of the extractrevealed the presence of alkaloids, phenolics, cardiac glycosides, flavonoids, terpenoid and steroid. Theextract administered to the infected mice significantly suppressed the parasite. The extract also significantly(P<0.05) reduced the activities of serum aspatate aminotransferase (AST), alkaline phosphate (ALP),alanine aminotransferase (ALT). White blood corpuscles (WBC), red blood corpuscles (RBC), hemoglobin(HGB), packed cell volume (PCV), platelets (PLT) and the mean corpuscular hemoglobin concentration(MCHC) showed significant (P<0.05) increase after the administration of the extract while mean corpuscularvolume (MCV) and the mean corpuscular hemoglobin (MCH) showed significant (P<0.05) reduction.Present findings suggests that the plant extract contains phytochemicals that have antiplasmodial andhepatoprotective properties.