Open AccessClick Chemistry: copper, ruthenium catalyzed and photoinduced
Author(s) -
Mitu De,
Santi Ranjan Dey
Publication year - 2021
Publication title -
international journal of experimental research and review
Language(s) - English
Resource type - Journals
ISSN - 2455-4855
DOI - 10.52756/ijerr.2021.v26.004
Subject(s) - click chemistry , cycloaddition , alkyne , chemistry , azide , combinatorial chemistry , ruthenium , schematic , triazole , nanotechnology , catalysis , organic chemistry , materials science , electronic engineering , engineering
Click chemistry is an extremely powerful method for covalent conjugation of molecular entities quickly and efficiently. Click chemistry knitted the threads between two different molecular entities that have created interesting structures for more than 15 years with a wide range of applications, including in interesting fields such as synthetic chemistry, medicinal science, biochemistry, material science, pharmacology and catalysis. Due to the schematic modification and incorporation of azide and alkyne groups within biological scaffolds, azide-alkyne cycloaddition (AAC) is still the leading methodology among click chemistry. This review focuses on the mechanism, scope, and applications of the CuAAC reaction, RuAAC reaction, and the recent development of photo-click reactions, and their applications cover the literature from the last ten years.